Starting GLP-1 medications like Semaglutide or Tirzepatide can be a powerful tool for weight loss, but it’s essential to understand the possible side effects. Knowing what to expect—whether common symptoms like nausea or less frequent concerns like gallbladder issues—can help you better navigate treatment and avoid surprises. Below is a quick review of both the typical and rare side effects of GLP-1 medications. There are many ways to cope with the side effects and new nutritional needs when taking a GLP-1. Often side effects are worse at the beginning of treatment and/or right after an injection and then wane.

Common Side Effects:

1. Gastrointestinal Issues: Nausea, bloating, vomiting, diarrhea, and constipation are the most frequent side effects, especially during the first few weeks of treatment.
2. Appetite Suppression: Reduced appetite is common and often desired, though it may sometimes lead to unintentional excessive weight loss.
3. Fatigue and Body Aches: Some users experience fatigue or mild body aches, which may subside as the body adjusts.
4. Feeling Cold: Rapid weight loss or appetite suppression can lead to a sensation of feeling cold, as metabolism and energy levels adjust.
5. Hair Loss: Hair loss may occur, likely due to rapid weight loss or changes in nutrient absorption, which can disrupt hair health.
6. Acne: Weight loss can affect hormone levels, potentially increasing androgen levels or releasing stored toxins, which can trigger acne.

Uncommon Side Effects:

1. Pancreatitis: Though rare, GLP-1 medications carry a risk of inflammation in the pancreas.
2. Gallbladder Issues: Increased risk of gallstones or cholecystitis, particularly with rapid weight loss.
3. Thyroid Tumors: A rare but serious risk, especially for those with a personal or family history of certain thyroid cancers.

If you experience severe or unusual symptoms, it’s essential to reach out to your healthcare provider promptly.

Some people reduce their dosage to lessen the impact of side effects and gradually increase their dosage over time.

While GLP-1 medications can bring transformative health benefits, awareness of potential side effects ensures you’re prepared to manage any challenges. If you experience symptoms that seem severe or unusual, don’t hesitate to consult your healthcare provider. By staying informed, you’ll be better equipped to handle any side effects and fully benefit from the positive impact these medications can offer on your health journey.